2024

  1. Nagagata BA, Brito G, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Melatonin supplementation in obese mothers reduces hypothalamic inflammation and enhances thermogenesis in mice progeny. J Nutr Biochem 2024 ; 128: 109625 (doi: 10.1016/j.jnutbio.2024.109625)
  2. Spezani R, Marinho TS, Santos-Reis T, Aguila MB, Mandarim-de-Lacerda CA. Cotadutide (GLP-1/Glucagon dual receptor agonist) modulates hypothalamic orexigenic and anorexigenic neuropeptides in obese mice. Peptides 2024; 173: 171138 (doi:10.1016/j.peptides.2023.171138).
  3. Spezani R, Reis-Barbosa P, Mandarim-de-Lacerda CA. Update on the transdifferentiation of pancreatic cells into functional beta cells for treating diabetes. Life Sciences, 2024:122645 (doi:10.1016/j.lfs.2024.122645)
  4.  

2023

  1. Ajackson M, Nagagata BA, Marcondes-de-Castro IA, Mandarim-de-Lacerda CA, Aguila MB. Adult mice offspring of obese mothers supplemented with melatonin show lessened liver steatosis, inflammation, oxidative stress, and endoplasmic reticulum stress. Life Sciences 2023;312:121253 (doi:10.1016/j.lfs.2022.121253)
  2. Azulay RD, Bravo B, Azulay V, Ronir R, Cuzzi T, Mandarim-de-Lacerda CA, Azulay M. Durability of the improvement of collagen I and III with the use of oral isotretinoin in the treatment of photoaging. Int J Dermatol 2023:e16868 (doi: 10.1111/ijd.16868)
  3. Cardoso LEM, Marinho TS, Martins FF, Aguila MB, Mandarim-de-Lacerda CA. Treatment with semaglutide, a GLP-1 receptor agonist, improves extracellular matrix remodeling in the pancreatic islet of diet-induced obese mice. Life Sci 2023;319:121502 (doi: 10.1016/j.lfs.2023.121502)
  4. Castro-de-Paiva P, Marinho TS, Mandarim-de-Lacerda CA, Aguila MB. High-intensity interval training (treadmill) effects in myokines and endoplasmic reticulum stress of calf muscles in obese mice. Int J Morphol 2023;41:591-599 (doi: 10.4067/S0717-9502202300020059)
  5. Marcondes-de-Castro IA, Oliveira TF, Spezani R, Marinho TS, Cardoso LEM, Aguila MB, Mandarim-de-Lacerda CA. Cotadutide effect in liver and adipose tissue in obese mice. J Mol Endocrinol 2023;70(3):e220168 (doi: 10,1530/JME-22-0168)
  6. Marcondes-de-Castro IA, Reis-Barbosa PH, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. AMPK/mTOR pathway significance in healthy liver and non-alcoholic fatty liver disease and its progression. J Gastroenterol Hepatol 2023;38(7):16272 (doi: 10.1111/jgh.16272)
  7. Martins FF, Santos-Reis T. Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Hypothalamic anorexigenic signaling pathways (leptin, amylin, and proopiomelanocortin) are semaglutide (GLP-1 analog) targets in obesity control in mice. Life Sciences 2023;313:121268 (doi: 10.1016/j.lfs.2022.121268)
  8. Nagagata BA, Ajackson M, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Obese mothers supplemented with melatonin during gestation and lactation ameliorate the male offspring’s pancreatic islet cellular composition and beta-cell function. J Dev Orig Health Dis 2023:1-11 (doi:10.1017/S2040174423000168)
  9. Petito-da-Silva TI, Villardi Jr FM, Penna-de-Carvalho A, Mandarim-de-Lacerda CA, Souza-Mello V, Barbosa-da-Silva S. An intestinal FXR agonist mitigates dysbiosis, intestinal tight junctions and inflammation in high-fat diet-fed mice. Mol Nut Food Res 2023; 2300148 (doi: 10.1002/mnfr.202300148)
  10. Santana-Oliveira DA, Tavares HS, Fernandes-da-Silva A, Silva-Veiga F, Casimiro-Lopes G, Lisboa PC, Mandarim-de-Lacerda CA, Souza-Mello V. Exercise (HIIT and MICT) prevents obesity by reducing gut-derived inflammatory signals to brown adipocytes in high-fat-fed mice. J Endocrinol 2023;259:2e230123 (doi: 10.1530/JOE-23-0123)
  11. Spezani R, Marinho TS, Cardoso LEM, Aguila MB, Mandarim-de-Lacerda CA. Pancreatic islet remodeling in cotadutide-treated obese mice. Life Sciences 2023;327:121858 (doi: 10.1016/j.lfs.2023.121858
  12. Spezani R, Marcondes-de-Castro IA, Marinho TS, Reis-Barbosa PH, Cardoso LEM, Aguila MB, Mandarim-de-Lacerda CA. Cotadutide improves brown adipose tissue thermogenesis in obese mice. Biochem Pharmacol 2023;217:115852 (doi:10.1016/j.bcp.2023.115852).

 

2022

  1. Araujo N, Orlando MM, Neves M, Souza R, Mandarim-de-Lacerda CA. Evaluation of spleen function in renal transplant patients and controls by liver-spleen scanning using qualitative and quantitative methods. Int J Innov Res Med Sci (IJIRMS) 2022;7 (3): 167-172 (doi: 10.23958/ijirms/vol07-i03/1373)
  2. Azevedo CR, Santana-Oliveira D, Miranda CS, Martins FF, Mandarim-de-Lacerda CA, Souza-Mello V. Progressive brown adipocyte dysfunction: whitening and impaired nonshivering thermogenesis as long-term obesity complications. J Nutr Biochem 2022;105:109002 (doi: 10.1016/j.jnutbio.2022.109002)
  3. Castro-de-Paiva P, Marinho TS, Mandarim-de-Lacerda CA, Aguila MB. Intermittent fasting, high-intensity interval training, or a combination of both have beneficial effects in obese mice with nonalcoholic fatty liver disease. J Nutr Biochem 2022;104:108997 (doi: 10.1016/j.jnutbio.2022.108997)
  4. Hubert J, Vouhe P, Poitout D, Bagot M, Pion M, Vuitton DA, Mandarim-de-Lacerda CA, Delmas V., et al. Rapport 21-13. Formation des chirurgiens/des équipes chirurgicales à la chirurgie robot-assistée. État de la situation actuelle. Propositions d’améliorations. Bull l’Acad Nat Méd 2022;206:167-78 (doi: 10.1016/j.banm.2021.12.008)
  5. Mandarim-de-Lacerda CA. The morphological challenge in determining nuclear size and shape in anatomopathological neoplasia analysis. Int J Morphol 2022;40:683-7 (doi: 10.4067/S0717-95022022000300683)
  6. Marinho TS, Martins FF, Cardoso LEM, Aguila MB, Mandarim-de-Lacerda CA. Pancreatic islet cells disarray, apoptosis, and proliferation in obese mice. The role of Semaglutide treatment. Biochimie 2022;193:126-136 (doi: 10.1016/j.biochi.2021.10.017)
  7. Martins FF, Marinho TS, Cardoso LEM, Barbosa-da-Silva S, Souza-Mello V, Aguila MB, Mandarim-de-Lacerda CA. Semaglutide (GLP-1 receptor agonist) stimulates browning on subcutaneous fat adipocytes and mitigates inflammation and endoplasmic reticulum stress in visceral fat adipocytes of obese mice. Cell Biochem Funct 2022;40::1-11 (doi: 10.1002/cbf.3751)
  8. Martins FF, Souza-Mello V, Aguila MB, Mandarim-de-Lacerda CA. Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines. Horm Mol Biol Clin Inv (HMBCI) 2022;43: 44-52 (doi: 10.1515/hmbci-2022-0044)
  9. Pontes-da-Silva RM, Marinho TS, Cardoso LEM, Mandarim-de-Lacerda CA, Aguila MB. Obese mice weight loss role on nonalcoholic fatty liver disease and endoplasmic reticulum stress treated by a GLP-1 receptor agonist. Int J Obes 2022;46:21-29 (doi: 10.1038/s41366-021-00955-7)
  10. Reis-Barbosa PH, Marcondes-de-Castro I, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. The mTORC1/AMPK pathway plays a role in the beneficial effects of semaglutide (GLP-1 receptor agonist) on the liver of obese mice. Clin Res Hepatol Gastroenterol 2022;46:101922  (doi: 10.1016/j.clinre.2022.101922)
  11. Reis-Barbosa PH, Marinho TS, Matsuura C, Aguila MB, Carvalho JJ, Mandarim-de-Lacerda CA. The obesity and nonalcoholic fatty liver disease mouse model revisited: liver oxidative stress, hepatocyte apoptosis, and proliferation. Acta Histochemica 2022;124(7):151937 (doi: 10.1016/j.acthis.2022.151937)
  12. Santana-Oliveira DA, Fernandes-da-Silva A, Santos Miranda C, Martins FF, Mandarim-de-Lacerda CA, Souza-Mello V. A PPAR-α agonist, and DPP-4 inhibitor mitigate adipocyte dysfunction in obese mice. J Mol Endocrinol 2022;68:225-241 (doi: 10.1530/JME-21-0084)
  13. Spezani R, Mandarim-de-Lacerda CA. The current significance and prospects for the use of dual receptor agonism GLP-1/Glucagon. Life Sciences  2022;288:120188 (doi: https://doi.org/10.1016/j.lfs.2021.120188)

 

2021

  1. Aguila MB, Ornellas F, Mandarim-de-Lacerda CA. Nutritional research and fetal programming: parental nutrition influences the structure and function of the organs. Int J Morphol 2021;39:327-334 (doi: 10.4067/S0717-95022021000100327)
  2. Mandarim-de-Lacerda CA, Del Sol M, Vasquez B, Aguila MB. Mice as an animal model for the study of adipose tissue and obesity. Int J Morphol 2021;39:1521-1528 (doi: 10.4067/S0717-95022021000601521)
  3. Martins FF; Souza-Mello V; Carvalho JJ; Del Sol M; Aguila MB, Mandarim-de-Lacerda CA. Liver structural injury in leptin-deficient (ob/ob -/-) mice: lipogenesis, fibrogenesis, inflammation, and apoptosis. Int J Morphol 2021; 39:732-738 (doi: 10.4067/S0717-95022021000300732).
  4. Reis-Barbosa PH, De Carvalho JJ, Del Sol M, Mandarim-de-Lacerda, CA. Hepatic mitochondria in diet-induced obese mice
    (stereology and molecular analysis). Int J Morphol, 2021;39(2):571-576 (doi: 10.4067/S0717-95022021000200571) 
  5. Tarevnic R, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Maternal swimming mitigates liver damage caused by paternal obesity. Nutrition 2021;86: 111168 (doi: 10.1016/j.nut.2021.111168)

 

2020

  1. Borges CC, Bringhenti I, Aguila MB, Mandarim-de-Lacerda CA. Vitamin D restriction enhances the periovarian adipose tissue inflammation in a model of menopause. Climacteric 2020;23:99-104(doi: 10.1080/13697137.2019.1597841)
  2. Carapeto PV, Mandarim-de-Lacerda CA, Aguila MB. Effects of Y1 receptor agonist on the pancreatic islet of diet-induced obese and diabetic mice. J Diabetes Complications 2020;34:107669 (doi: 10.1016/j.jdiacomp.2020.107669)
  3. Filomeno CES, Costa-Silva M, Correa CL, Neves RH, Mandarim-de-Lacerda CA, Machado-Silva JR. The acute schistosomiasis mansoni ameliorates metabolic syndrome in the C57BL/6 mouse model. Exp Parasitol 2020; 212: 107889 (doi: 10.1016/j.exppara.2020.107889)
  4. Marinho TS, Borges CC, Aguila MB, Mandarim-de-Lacerda CA. Intermittent fasting benefits on alpha- and beta-cell arrangement in diet-induced obese mice pancreatic islet. J Diab Complications 2020; 34: 107497 (doi: 10.1016/j.jdiacomp.2019.107497)
  5. Marinho TS, Ornellas F, Aguila MB, Mandarim-de-Lacerda CA. Browning of the subcutaneous adipocytes in diet-induced obese mouse submitted to intermittent fasting. Mol Cell Endocrinol 2020;513:110872 (doi: 10.1016/j.mce.2020.110872)
  6. Martins FF, Aguila MB, Mandarim-de-Lacerda CA. Eicosapentaenoic and docosapentaenoic acids lessen the expression of PPARγ / Cidec affecting adipogenesis in cultured 3T3-L1 adipocytes. Acta Histochemica 2020; 122: 151504 (doi:10.1016/j.acthis.2020.151504)
  7. Miranda CA, Silva-Veiga F, Martins FF, Rachid TL, Mandarim-de-Lacerda CA, Souza-Mello V. PPAR-alpha activation counters brown adipose tissue whitening: a comparative study between high-fat and high-fructose-fed mice. Nutrition 2020; 78: 110791 (doi: 10.1016/j.nut.2020.110791)
  8. Oliveira F, Correia B, Marinho TS, Barbosa-da-Silva S, Mandarim-de-Lacerda CA, Souza-Mello V. Anti-steatotic linagliptin pleiotropic effects encompasses suppression of de novo lipogenesis and ER stress in high-fat-fed mice. Mol Cell Endocrinol 2020;509: 110804 (doi: 10.1016/j.mce.2020.110804)
  9. Ornellas F, Karise I, Aguila MB, Mandarim-de-Lacerda CA. Pancreatic islets of Langerhans: adapting cell and molecular biology to changes of metabolism. In: Faintuch J, Faintuch S (eds) Obesity and diabetes. Springer, Cham. 2020, https://doi.org/10.1007/978-3-030-53370-0_13
  10. Ornellas F, Carapeto PV, Aguila MB, Mandarim-de-Lacerda CA. Sex-linked changes and high cardiovascular risk markers in the mature progeny of father, mother, or father and mother together consuming a high-fructose diet. Nutrition 2020; 71: 110612 (doi: 10.1016/j.nut.2019.110612)
  11. Reis-Barbosa PH, Carvalho JJ, Del Sol M, Mandarim-de-Lacerda CA. Commentary on mitochondrial stereology in transmission electron microscopy. Int J Morphol 2020; 38: 26-29 (doi: 10.4067/S0717-95022020000100026)
  12. Silva-Veiga FM, Miranda CS, Martins FF, Daleprane JB, Mandarim-de-Lacerda CA, Souza-Mello V. PPAR-alpha activation and DPP-4 inhibition mitigate liver steatosis through gut-liver axis modulation in high-fructose-fed mice. J Endocrinol 2020;247:11-24 (doi: 10.1530/JOE-20-0139)
  13. Spezani R, Silva RR, Martins FF, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Intermittent fasting, adipokines, insulin sensitivity, and hypothalamic neuropeptides in a dietary overload with high-fat or high-fructose diet in mice. J Nutrit Biochem 2020;83:108419 (doi: 10.1016/j.jnutbio.2020.108419)

 

2019

  1. Bargut TCL, Martins FF, Santos LP, Aguila MB, Mandarim-de-Lacerda CA. Administration of eicosapentaenoic and docosahexaenoic acids may improve the remodeling and browning in subcutaneous white adipose tissue and thermogenic markers in brown adipose tissue in mice. Mol Cell Endocrinol 2019;482:18-27 (doi: 10.1016/j.mce.2018.12.003)
  2. Correia BRO, Rachid TL, Glauser, JSO, Martins, FF, Mandarim-de-Lacerda CA, Souza-Mello V. Linagliptin induces browning of the subcutaneous white adipose tissue in diet-induced obese C57BL/6 mice. Endocrine 2019;65:252-262 (doi: 10.1007/s12020-019-01969-y)
  3. Guimaraes J, Bargut TCL, Mandarim-de-Lacerda CA, Aguila MB. Medium-chain triglyceride reinforce the hepatic damage caused by fructose intake in mice. Prostaglandins, Leukotrienes and Essential Fatty Acids 2019;140:64-71 (doi: 10.1016/j.plefa.2018.11.005)
  4. Karise I, Bargut TC, Del Sol M, Aguila MB, Mandarim-de-Lacerda CA. Metformin enhances mitochondrial biogenesis and thermogenesis in brown adipocytes of mice. Biomed Pharmacother 2019;111;1156-1165 (doi: 10.1016/j.biopha.2019.01.021)
  5. Maia-Ceciliano TC, Dutra RR, Aguila MB, Mandarim-de-Lacerda CA. The deficiency and the supplementation of vitamin D and liver: lessons of chronic fructose-rich diet in mice. J Steroid Biochem Mol Biol 2019;192:105399 (doi: 10.1016/j.jsbmb.2019.105399)
  6. Mandarim-de-Lacerda CA. L’îlot pancréatique : ce que nous savons 150 ans après Langerhans. Bull Acad Nationale Méd (France) 2019;203;670-682 \(doi: 10.1016/j.banm.2019.06.015)
  7. Mandarim-de-Lacerda CA. Breve história da anatomia, com ênfase no sistema cardiovascular. Anais Acad Nac Med 2019;190(2):23-33.
  8. Mandarim-de-Lacerda, CA. Ontogenetic and phylogenetic allometry (bivariate and multivariate) for young morphologists. Int J Morphol 2019;37(2):466-472 (doi: 10.4067/S0717-95022019000200466)
  9. Mandarim-de-Lacerda, CA. Pancreatic islet (of Langerhans) revisited. Histology and Histopathology 2019;34:985-993 (doi: 10.14670/HH-18-118)
  10. Mandarim-de-Lacerda CA. A brief introduction to the evolutionary anatomy of the skull and face in the genus Homo. J Health Med Sci 2019;5:107-111 (http://www.johamsc.com/wp-content/uploads/2019/07/JOHAMSC-52-107-111-2019-.pdf)
  11. Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Pancreatic islet stereology: estimation of beta cell mass. Int J Morphol 2019; 37:1331-1334 (doi: 10.4067/S0717-95022019000401331)
  12. Marinho TS, Ornellas F, Barbosa-da-Silva S, Mandarim-de-Lacerda CA, Aguila MB. Intermittent fasting beneficial effects on the steatosis and inflammation of the liver in mice fed a high-fat or a high-fructose diet. Nutrition 2019;65:103-112 (doi: 10.1016/j.nut.2019.02.020)
  13. Motta VF, Bargut TL, Souza-Mello V, Aguila MB, Mandarim-de-Lacerda CA. Browning is activated in the subcutaneous white adipose tissue of mice metabolically challenged with a high-fructose diet submitted to high-intensity interval training. J Nutr Biochem 2019;70:164-173 (doi: 10.1016/j.jnutbio.2019.05.008)
  14. Tarevnic R, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Beneficial effects of maternal swimming during pregnancy on offspring metabolism when the father is obese. Journal of Developmental Origins of Health and Disease 2019;10:502-506 (doi: 10.1017/S2040174418001046)

2018

  1. Borges CC, Bringhenti I, Mandarim-da-Lacerda CA, Aguila MB. Vitamin D deficiency aggravates the liver metabolism and inflammation in ovariectomized mice. Biomed Pharmacotherap 2018;107:878-888 (doi: 10.1016/j.biopha.2018.08.075)
  2. Borges CC, Salles AF, Brighenti I, Mandarim-de-Lacerda CA, Aguila MB. Vitamin D deficiency increases lipogenesis and reduces beta-oxidation in the liver of diet-induced obese mice. J Nutr Sci Vitaminol 2018;64(2):106-115 (doi: 10.3177/jnsv.64.106)
  3. Carapeto PV, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Liver metabolism in adult male mice offspring: consequences of a maternal, paternal, or both maternal and paternal high-fructose diet. J Development Origins Health Dis (DOHaD) 2018;9:450-459(doi: 10.1017/S2040174418000235)
  4. Ornellas F, Bringhenti I, Mattos BA, Mandarim-de-Lacerda CA, Aguila MB. Father’s obesity programs the adipose tissue in the offspring via the local renin-angiotensin system and MAPKs pathways, especially in adult male mice. Eur J Nutr 2018;57:1901-1912(doi: 10.1007/s00394-017-1473-4)
  5. Rachid TL, Silva-Veiga FM, Graus-Nunes F, Bringhenti I, Mandarim-de-Lacerda CA, Souza-Mello V. Differential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice. PLoS ONE 13(1): e0191365 (doi: 10.1371/journal.pone.0191365)
  6. Silva-Veiga FM, Rachid TL, Oliveira L, Graus-Nunes F, Mandarim-de-Lacerda CA, Souza-Mello V. GW0742 (PPAR-beta agonist) attenuates hepatic endoplasmic reticulum stress by improving hepatic energy metabolism in mice fed a high-fat diet. Mol Cell Endocrinol 2018;474:227-237 (doi: 10.1016/j.mce.2018.03.013)