{"id":682,"date":"2018-12-06T10:20:58","date_gmt":"2018-12-06T13:20:58","guid":{"rendered":"http:\/\/www.lmmc.uerj.br\/?page_id=682"},"modified":"2026-10-21T11:17:14","modified_gmt":"2026-10-21T14:17:14","slug":"2019-2","status":"publish","type":"page","link":"https:\/\/www.lmmc.uerj.br\/?page_id=682","title":{"rendered":"Recent"},"content":{"rendered":"

2026<\/h3>\r\n
    \r\n
  1. Aguila MB, Mandarim-de-Lacerda CA. DHA as a systems regulator of neuroinflammation: A narrative review integrating membrane organization, immunometabolism, and inflammatory resolution.<\/strong> Histol Histopathol<\/em> 2026:25155, doi: 10.14670\/HH-25-155<\/a>.<\/li>\r\n
  2. Bittencourt JOA, Giannini JF, Guarnieri RS, Marinho TS, Penna-de-Carvalho A, Reis-Barbosa PH, Aguila MB, Mandarim-de-Lacerda CA. Neuroinflammation as a Central Axis in Brain Aging and Neurodegenerative Diseases: Mechanisms, Functional Consequences, and Therapeutic Perspectives.<\/strong> Anais Acad Nac Med<\/em> 2026; 197:<\/strong> 11-27 (doi:10.52130\/27639878-AANM2026v197n1p11-27<\/a>).<\/li>\r\n
  3. Bittencourt JOA, Marcondes-de-Castro IA, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Tirzepatide Counteracts Brown Adipose Tissue Whitening, Inflammation, and Mitochondrial Dysfunction in Estrogen-Deficient Obese Diabetic Mice. <\/strong>Life Sci <\/em>2026;386:<\/strong>124155 (doi: 10.1016\/j.lfs.2025.124155<\/a>)\u00a0<\/li>\r\n
  4. Mandarim-de-Lacerda CA. A Socratic-Platonic dialogue on quantitative morphology and stereological inference.<\/strong> Int J Morphol<\/em> 2026;44<\/strong>(3):829-841 (doi: 10.4067\/s0717-95022026000300829<\/a>)<\/li>\r\n
  5. Mandarim-de-Lacerda CA. Escola anat\u00f4mica do Rio de Janeiro: institui\u00e7\u00f5es, evolu\u00e7\u00e3o hist\u00f3rica e legado (1808\u20131950). <\/strong>Anais Acad Nac Med\u00a0<\/em>2026;193<\/strong>(3): 40-65 (doi: 10.52130\/27639878-AANM2026v197n3p40-65<\/a>)<\/li>\r\n
  6. Mandarim-de-Lacerda CA, Spezani R. Diab\u00e8te, ob\u00e9sit\u00e9 et neurod\u00e9g\u00e9n\u00e9rescence\u00a0: les agonistes du r\u00e9cepteur du GLP-1 comme modulateurs du continuum m\u00e9tabolique\u2013neuro-inflammatoire.<\/strong> Bulletin de l’Acad\u00e9mie Nationale de M\u00e9decine<\/em> 2026;210<\/strong> (7):852-9, doi: 10.1016\/j.banm.2026.04.020<\/a>.<\/li>\r\n
  7. Marcondes-de-Castro IA, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Tirzepatide Attenuates Estrogen Deficiency-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Progression by Reducing Steatosis, Inflammation, and Fibrosis in Obese-Diabetic Mice. <\/strong>Menopause<\/em> 2026;33:<\/strong>460-470\u00a0 (doi: 10.1097\/GME.0000000000002683<\/a>)<\/span><\/li>\r\n
  8. Marcondes-de-Castro IA, Sales TA, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Redox-sensitive coordination of mitochondrial quality control: Integrating ROS, NAD(+), and Ca(2+) signaling in disease.<\/strong> Life Sci<\/em> 2026;403:<\/strong>124642, doi:10.1016\/j.lfs.2026.124642<\/a>.<\/li>\r\n
  9. Marinho TS, Bittencourt JOA, Aguila MB, Mandarim-de-Lacerda CA. Tirzepatide Reverses Hypothalamic Inflammation, Cellular Stress, and Neuropeptide Imbalance in Metabolic\u2013Menopausal Dysfunction. <\/strong>Brain Res\u00a0<\/em>2026;1872:<\/strong>150113 (doi: 10.1016\/j.brainres.2025.150113<\/a>)<\/li>\r\n
  10. Penna-de-Carvalho A, Nagagata BA, Guarnieri RS, Borges MMS, Teixeira LPM, Ferreira-Machado SC, Aguila MB.\u00a0Metabolic Adaptations and Dietary Preferences in Mice Exposed to Ketogenic and High-Fat High-Sucrose Diets.\u00a0<\/strong>Nutrition<\/em> 2026;143:<\/strong>113037 (doi: 10.1016\/j.nut.2025.113037<\/a>)\u00a0<\/li>\r\n
  11. Spezani R, Mandarim-de-Lacerda CA. Beyond Diabetes and Obesity: GLP-1 Receptor Agonists in Disrupting the Vicious Cycle of Metabolic Dysfunction and Neuroinflammation. <\/strong>Diabetes Obes Metab. <\/em>2026;28:<\/strong>1622-1637 (doi:10.1111\/dom.70400<\/a>)<\/span><\/li>\r\n<\/ol>\r\n

    \u00a0<\/h3>\r\n

    2025<\/h3>\r\n
      \r\n
    1. Fabiano MM, Aguila MB, Mandarim-de-Lacerda CA. The Hypothalamus and Hippocampus are Targets for New Drugs Controlling the Energy Balance and Treating Type 2 Diabetes Mellitus, Obesity, and Neurodegenerative Diseases.<\/strong> Int J Morphol<\/em> 2025;43<\/strong>(1):182-193 (doi: 10.4067\/S0717-95022025000100182<\/a>).<\/li>\r\n
    2. Fernandes-da-Silva A, Santana-Oliveira DA, Miranda RA, Souza-Tavares H, Silva-Veiga F, Mandarim-de-Lacerda CA, Souza-Mello V. Dual PPAR-a\/g enhances beta cell identity, preserving islet structure in HF-fed mice. <\/strong>J Endocrinol<\/em> 2025;264:<\/strong>e240180 (doi:10.1530\/JOE-24-0180<\/a>)<\/li>\r\n
    3. Mandarim-de-Lacerda CA. Two millennia of anatomical discovery: shaping the evolution of medicine.<\/strong> Int J Morphol<\/em> 2025;43<\/strong>(3): 891-900 (doi: 10.4067\/S0717-95022025000300891<\/a>)\u00a0<\/li>\r\n
    4. Mandarim-de-Lacerda CA. Da encefaliza\u00e7\u00e3o ao bipedalismo: li\u00e7\u00f5es da evolu\u00e7\u00e3o humana para a sa\u00fade contempor\u00e2nea.<\/strong> Anais da Acad Nac Medicina<\/em> 2025;196<\/strong>(3):52-67 (doi: 10.52130\/27639878-AANM2025v196n3p52-67<\/a>)<\/li>\r\n
    5. Marcondes-de-Castro IA, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Tirzepatide Enhances Liver Structural Integrity by Promoting Mitochondrial Dynamics and Mitophagy via PINK1\/PRKN and SIRT3\/NRF2 Pathways in an Obese-Diabetic-Menopausal Mouse Model<\/strong>. Tissue and Cell<\/em> 2025:103146, doi:10.1016\/j.tice.2025.103146<\/a>.<\/li>\r\n
    6. Marinho TS, Fabiano MM, Aguila MB, Mandarim-de-Lacerda CA.Principal Components Analysis on Genes Related to Inflammasome Complex and Microglial Activation in the Hypothalamus of obese mice treated with Semaglutide (GLP-1 analog).<\/strong>\u00a0Brain Res<\/em> 2025;1846:<\/strong>149225 (doi:\u00a010.1016\/j.brainres.2024.149225<\/a>)<\/li>\r\n
    7. Reis-Barbosa PH, Cardoso LEM, Mandarim-de-Lacerda CA. Tirzepatide Improves Extracellular Matrix Integrity and Vascularization in Pancreatic Islets of a Mouse Model of Obesity, Diabetes, and Menopause.<\/strong> Biochemical and Biophysical Research Communications<\/em> (BBRC) 2025;790<\/strong>:e152913 (doi: 10.1016\/j.bbrc.2025.152913<\/a>)<\/li>\r\n
    8. Silva-Veiga FM, Marinho TS, Souza-Mello V, Aguila MB, Mandarim-de-Lacerda CA. Tirzepatide, a dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), positively impacts the altered microbiota of obese, diabetic, ovariectomized mice. <\/strong>Life Sciences <\/em>2025;361:<\/strong>123310 (doi: 10.1016\/j.lfs.2024.123310<\/a>)<\/li>\r\n
    9. Silva-Veiga FM, Miranda CS, Santana-Oliveira DA, Fernandes-da-Silva A, Mandarim-de-Lacerda CA, Souza-Mello V. Excessive dietary fat and fructose enhance hepatic lipogenesis and impair mitochondrial dynamics to cause MASLD in C57BL\/6 mice.<\/strong> Obes Res Clin Pract<\/em> 2025;19<\/strong>(2):138-145 (doi: 10.1016\/j.orcp.2025.03.007<\/a><\/li>\r\n<\/ol>\r\n

      2024<\/h3>\r\n
        \r\n
      1. Nagagata BA, Brito G, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Melatonin supplementation in obese mothers reduces hypothalamic inflammation and enhances thermogenesis in mice progeny. <\/strong>J Nutr Biochem<\/em> 2024 ; 128:<\/strong> 109625 (doi: 10.1016\/j.jnutbio.2024.109625<\/a>)<\/li>\r\n
      2. Nagagata BA, Mandarim-de-Lacerda CA, Aguila MB. Melatonin-supplemented obese female mice show less inflammation in ovarian adipocytes and browning in subcutaneous adipocytes. <\/strong>Cell Biochemistry and Function <\/em>2024;42<\/strong>(8):e70034 (doi: 10.1002\/cbf.70034<\/a>)<\/li>\r\n
      3. Reis-Barbosa PH, Mandarim-de-Lacerda, CA. Sodium-glucose cotransporter-2 inhibitor (SGLT2i) plus glucagon-like peptide type 1 receptor combination is more effective than SGLT2i plus dipeptidyl peptidase-4 inhibitor combination in treating obese mice metabolic dysfunction-associated steatotic liver disease (MASLD). <\/strong>Fund Clin Pharmacol <\/em>2024:e13024<\/em> (doi: 10.1111\/fcp.13024<\/a>)<\/li>\r\n
      4. Reis-Barbosa PH, Marcondes-de-Castro IA, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. The dual GIP\/GLP-1 receptor agonist tirzepatide effects on bodyweight evolution, adiponectin, insulin, and leptin levels in the combination of obesity, type 2 diabetes, and menopause in mice. <\/strong>Diab Obes Metabol<\/em> 2024;26<\/strong>(10):4613-4621 (doi: 10.1111\/dom.15820<\/a>)<\/li>\r\n
      5. Reis-Barbosa PH, Aguila MB, Mandarim-de-Lacerda CA. Tirzepatide, a dual receptor agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, enhances beta-cell survival and maintenance markers in obese diabetic ovariectomized mice.<\/strong> Diabetes Obes Metab<\/em> 2024;26:<\/strong>6062-6 (doi:10.1111\/dom.15937<\/a>)<\/li>\r\n
      6. Spezani R, Marinho TS, Santos-Reis T, Aguila MB, Mandarim-de-Lacerda CA. Cotadutide (GLP-1\/Glucagon dual receptor agonist) modulates hypothalamic orexigenic and anorexigenic neuropeptides in obese mice. <\/strong>Peptides<\/em> 2024; 173:<\/strong> 171138 (doi:10.1016\/j.peptides.2023.171138<\/a>).<\/li>\r\n
      7. Spezani R, Reis-Barbosa P, Mandarim-de-Lacerda CA. Update on the transdifferentiation of pancreatic cells into functional beta cells for treating diabetes. <\/strong>Life Sciences<\/em>, 2024:122645 (doi:10.1016\/j.lfs.2024.122645<\/a>)<\/li>\r\n<\/ol>\r\n

        2023<\/h3>\r\n
          \r\n
        1. Ajackson M, Nagagata BA, Marcondes-de-Castro IA, Mandarim-de-Lacerda CA, Aguila MB. Adult mice offspring of obese mothers supplemented with melatonin show lessened liver steatosis, inflammation, oxidative stress, and endoplasmic reticulum stress. <\/strong>Life Sciences<\/em> 2023;312:<\/strong>121253 (doi:10.1016\/j.lfs.2022.121253<\/a>)<\/li>\r\n
        2. Azulay RD, Bravo B, Azulay V, Ronir R, Cuzzi T, Mandarim-de-Lacerda CA, Azulay M. Durability of the improvement of collagen I and III with the use of oral isotretinoin in the treatment of photoaging.<\/strong> Int J Dermatol<\/em> 2023:e16868 (doi: 10.1111\/ijd.16868<\/a>)<\/li>\r\n
        3. Cardoso LEM, Marinho TS, Martins FF, Aguila MB, Mandarim-de-Lacerda CA. Treatment with semaglutide, a GLP-1 receptor agonist, improves extracellular matrix remodeling in the pancreatic islet of diet-induced obese mice. <\/strong>Life Sci <\/em>2023;319:<\/strong>121502 (doi: 10.1016\/j.lfs.2023.121502<\/a>)<\/li>\r\n
        4. Castro-de-Paiva P, Marinho TS, Mandarim-de-Lacerda CA, Aguila MB. High-intensity interval training (treadmill) effects in myokines and endoplasmic reticulum stress of calf muscles in obese mice. <\/strong>Int J Morphol\u00a0<\/em>2023;41:<\/strong>591-599 (doi: 10.4067\/S0717-9502202300020059<\/a>)<\/li>\r\n
        5. Marcondes-de-Castro IA, Oliveira TF, Spezani R, Marinho TS, Cardoso LEM, Aguila MB, Mandarim-de-Lacerda CA. Cotadutide effect in liver and adipose tissue in obese mice. <\/strong>J Mol Endocrinol <\/em>2023;70<\/strong>(3):e220168 (doi: 10,1530\/JME-22-0168<\/a>)<\/li>\r\n
        6. Marcondes-de-Castro IA, Reis-Barbosa PH, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. AMPK\/mTOR pathway significance in healthy liver and non-alcoholic fatty liver disease and its progression<\/strong>.<\/strong> J Gastroenterol Hepatol<\/em> 2023;38<\/strong>(7):16272 (doi: 10.1111\/jgh.16272<\/a>)<\/li>\r\n
        7. Martins FF, Santos-Reis T. Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Hypothalamic anorexigenic signaling pathways (leptin, amylin, and proopiomelanocortin) are semaglutide (GLP-1 analog) targets in obesity control in mice. <\/strong>Life Sciences <\/em>2023;313:<\/strong>121268 (doi: 10.1016\/j.lfs.2022.121268<\/a>)<\/li>\r\n
        8. Nagagata BA, Ajackson M, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Obese mothers supplemented with melatonin during gestation and lactation ameliorate the male offspring’s pancreatic islet cellular composition and beta-cell function. <\/strong>J Dev Orig Health Dis <\/em>2023:1-11\u00a0(doi:10.1017\/S2040174423000168<\/a>)<\/li>\r\n
        9. \r\n
          Petito-da-Silva TI,<\/a> Villardi Jr FM, Penna-de-Carvalho A, Mandarim-de-Lacerda CA, Souza-Mello V, Barbosa-da-Silva S. An intestinal FXR agonist mitigates dysbiosis, intestinal tight junctions and inflammation in high-fat diet-fed mice. <\/strong>Mol Nut Food Res<\/em> 2023; 2300148 (doi: 10.1002\/mnfr.202300148<\/a>)<\/div>\r\n<\/li>\r\n
        10. Santana-Oliveira DA, Tavares HS, Fernandes-da-Silva A, Silva-Veiga F, Casimiro-Lopes G, Lisboa PC, Mandarim-de-Lacerda CA, Souza-Mello V. Exercise (HIIT and MICT) prevents obesity by reducing gut-derived inflammatory signals to brown adipocytes in high-fat-fed mice. <\/strong>J Endocrinol<\/em> 2023;259:<\/strong>2e230123 (doi: 10.1530\/JOE-23-0123<\/a>)<\/li>\r\n
        11. Spezani R, Marinho TS, Cardoso LEM, Aguila MB, Mandarim-de-Lacerda CA. Pancreatic islet remodeling in cotadutide-treated obese mice. <\/strong>Life Sciences <\/em>2023;327:<\/strong>121858 (doi: 10.1016\/j.lfs.2023.121858<\/a><\/li>\r\n
        12. Spezani R, Marcondes-de-Castro IA, Marinho TS, Reis-Barbosa PH, Cardoso LEM, Aguila MB, Mandarim-de-Lacerda CA. Cotadutide improves brown adipose tissue thermogenesis in obese mice.<\/strong> Biochem Pharmacol <\/em>2023;217:<\/strong>115852 (doi:10.1016\/j.bcp.2023.115852<\/a>).<\/li>\r\n<\/ol>\r\n

          \u00a0<\/h3>\r\n

          2022<\/h3>\r\n
            \r\n
          1. Araujo N, Orlando MM, Neves M, Souza R, Mandarim-de-Lacerda CA. Evaluation of spleen function in renal transplant patients and controls by liver-spleen scanning using qualitative and quantitative methods.<\/strong> Int J Innov Res Med Sci (IJIRMS)\u00a0<\/strong><\/em>2022;7<\/strong> (3): 167-172 (doi: 10.23958\/ijirms\/vol07-i03\/1373<\/a>)<\/li>\r\n
          2. Azevedo CR, Santana-Oliveira D, Miranda CS, Martins FF, Mandarim-de-Lacerda CA, Souza-Mello V. Progressive brown adipocyte dysfunction: whitening and impaired nonshivering thermogenesis as long-term obesity complications. <\/strong>J Nutr Biochem <\/em>2022;105:<\/strong>109002 (doi: 10.1016\/j.jnutbio.2022.109002<\/a>)<\/li>\r\n
          3. Castro-de-Paiva P, Marinho TS, Mandarim-de-Lacerda CA, Aguila MB. Intermittent fasting, high-intensity interval training, or a combination of both have beneficial effects in obese mice with nonalcoholic fatty liver disease. <\/strong>J Nutr Biochem <\/em>2022;104:<\/strong>108997<\/span> (doi: 10.1016\/j.jnutbio.2022.108997<\/a>)<\/li>\r\n
          4. Hubert J, Vouhe P, Poitout D, Bagot M, Pion M, Vuitton DA, Mandarim-de-Lacerda CA, Delmas V., et al. Rapport 21-13. Formation des chirurgiens\/des \u00e9quipes chirurgicales \u00e0 la chirurgie robot-assist\u00e9e. \u00c9tat de la situation actuelle. Propositions d\u2019am\u00e9liorations.<\/strong> Bull l’Acad Nat M\u00e9d<\/em> 2022;<\/strong>206:167-78 (doi: 10.1016\/j.banm.2021.12.008<\/a>)<\/li>\r\n
          5. Mandarim-de-Lacerda CA. The morphological challenge in determining nuclear size and shape in anatomopathological neoplasia analysis.<\/strong> Int J Morphol<\/em> 2022;40:<\/strong>683-7 (doi: 10.4067\/S0717-95022022000300683<\/a>)<\/li>\r\n
          6. Marinho TS, Martins FF, Cardoso LEM, Aguila MB, Mandarim-de-Lacerda CA. Pancreatic islet cells disarray, apoptosis, and proliferation in obese mice. The role of Semaglutide treatment. <\/strong>Biochimie <\/em>2022;193:<\/strong>126-136 (doi: 10.1016\/j.biochi.2021.10.017<\/a>)<\/li>\r\n
          7. Martins FF, Marinho TS, Cardoso LEM, Barbosa-da-Silva S, Souza-Mello V, Aguila MB, Mandarim-de-Lacerda CA. Semaglutide (GLP-1 receptor agonist) stimulates browning on subcutaneous fat adipocytes and mitigates inflammation and endoplasmic reticulum stress in visceral fat adipocytes of obese mice<\/strong>. Cell Biochem Funct <\/em>2022;40:<\/strong>:1-11 (doi: 10.1002\/cbf.3751<\/a>)<\/li>\r\n
          8. Martins FF, Souza-Mello V, Aguila MB, Mandarim-de-Lacerda CA. Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines. <\/strong>Horm Mol Biol Clin Inv <\/em>(HMBCI) 2022;43:<\/strong> 44-52 (doi: 10.1515\/hmbci-2022-0044<\/a>)<\/li>\r\n
          9. Pontes-da-Silva RM, Marinho TS, Cardoso LEM, Mandarim-de-Lacerda CA, Aguila MB. <\/strong>Obese mice weight loss role on nonalcoholic fatty liver disease and endoplasmic reticulum stress treated by a GLP-1 receptor agonist. <\/strong>Int J Obes <\/em>2022;46:<\/strong>21-29 (doi: 10.1038\/s41366-021-00955-7<\/a>)<\/em><\/li>\r\n
          10. Reis-Barbosa PH, Marcondes-de-Castro I, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. The mTORC1\/AMPK pathway plays a role in the beneficial effects of semaglutide (GLP-1 receptor agonist) on the liver of obese mice. <\/strong>Clin Res Hepatol Gastroenterol<\/em> 2022;46:<\/strong>101922 \u00a0<\/em>(doi: 10.1016\/j.clinre.2022.101922<\/a>)<\/li>\r\n
          11. Reis-Barbosa PH, Marinho TS, Matsuura C, Aguila MB, Carvalho JJ, Mandarim-de-Lacerda CA. The obesity and nonalcoholic fatty liver disease mouse model revisited: liver oxidative stress, hepatocyte apoptosis, and proliferation. <\/strong>Acta Histochemica<\/em> 2022;124<\/strong>(7):151937 (doi: 10.1016\/j.acthis.2022.151937)<\/a><\/li>\r\n
          12. Santana-Oliveira DA, Fernandes-da-Silva A, Santos Miranda C, Martins FF, Mandarim-de-Lacerda CA, Souza-Mello V. A PPAR-<\/strong>\u03b1<\/strong> agonist, and DPP-4 inhibitor mitigate adipocyte dysfunction in obese mice. <\/strong>J Mol Endocrinol<\/em> 2022;68:<\/strong>225-241 (doi: 10.1530\/JME-21-0084<\/a>)<\/li>\r\n
          13. Spezani R, Mandarim-de-Lacerda CA. The current significance and prospects for the use of dual receptor agonism GLP-1\/Glucagon. <\/strong>Life Sciences\u00a0<\/em> 2022;288:<\/strong>120188 (doi: https:\/\/doi.org\/10.1016\/j.lfs.2021.120188<\/a>)<\/li>\r\n<\/ol>\r\n

            \u00a0<\/h3>\r\n

            2021<\/h3>\r\n
              \r\n
            1. Aguila MB, Ornellas F, Mandarim-de-Lacerda CA. Nutritional research and fetal programming: parental nutrition influences the structure and function of the organs. <\/strong>Int J Morphol<\/em> 2021;39:<\/strong>327-334 (doi: 10.4067\/S0717-95022021000100327<\/a>)<\/li>\r\n
            2. Mandarim-de-Lacerda CA, Del Sol M, Vasquez B, Aguila MB. Mice as an animal model for the study of adipose tissue and obesity.<\/strong> Int J Morphol<\/em> 2021;39:<\/strong>1521-1528 (doi: 10.4067\/S0717-95022021000601521<\/a>)<\/li>\r\n
            3. Martins FF; Souza-Mello V; Carvalho JJ; Del Sol M; Aguila MB, Mandarim-de-Lacerda CA. Liver structural injury in leptin-deficient (ob\/ob -\/-) mice: lipogenesis, fibrogenesis, inflammation, and apoptosis. <\/strong>Int J Morphol<\/em> 2021; 39<\/em><\/strong>:<\/strong>732-738 (doi: 10.4067\/S0717-95022021000300732<\/a>).<\/li>\r\n
            4. Reis-Barbosa PH, De Carvalho JJ, Del Sol M, Mandarim-de-Lacerda, CA. Hepatic mitochondria in diet-induced obese mice<\/strong>
              (stereology and molecular analysis).<\/strong> Int J Morphol<\/em>, 2021;39<\/strong>(2):571-576 (doi:               10.4067\/S0717-95022021000200571<\/a>)\u00a0<\/span><\/li>\r\n
            5. Tarevnic R, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Maternal swimming mitigates liver damage caused by paternal obesity. <\/strong>Nutrition <\/em>2021;86:<\/strong> 111168 (doi: 10.1016\/j.nut.2021.111168<\/a>)<\/li>\r\n<\/ol>\r\n

              \u00a0<\/h3>\r\n

              2020<\/h3>\r\n
                \r\n
              1. Borges CC, Bringhenti I, Aguila MB, Mandarim-de-Lacerda CA. Vitamin D restriction enhances the periovarian adipose tissue inflammation in a model of menopause. <\/strong>Climacteric <\/em>2020;23:<\/strong>99-104(doi:\u00a010.1080\/13697137.2019.1597841<\/a>)<\/li>\r\n
              2. Carapeto PV, Mandarim-de-Lacerda CA, Aguila MB. Effects of Y1 receptor agonist on the pancreatic islet of diet-induced obese and diabetic mice. <\/strong>J Diabetes Complications <\/em>2020;34:<\/strong>107669 (doi: 10.1016\/j.jdiacomp.2020.107669<\/a>)<\/li>\r\n
              3. Filomeno CES, Costa-Silva M, Correa CL, Neves RH, Mandarim-de-Lacerda CA, Machado-Silva JR. The acute schistosomiasis mansoni ameliorates metabolic syndrome in the C57BL\/6 mouse model.<\/strong> Exp Parasitol<\/em> 2020; 212: <\/strong>107889 (doi: 10.1016\/j.exppara.2020.107889<\/a>)<\/li>\r\n
              4. Marinho TS, Borges CC, Aguila MB, Mandarim-de-Lacerda CA. Intermittent fasting benefits<\/strong> on alpha- and beta-cell arrangement in diet-induced obese mice pancreatic\u00a0islet.<\/strong> J Diab Complications<\/em> 2020; 34: <\/strong>107497 (doi: 10.1016\/<\/a>j.jdiacomp.2019.107497)<\/li>\r\n
              5. Marinho TS, Ornellas F, Aguila MB, Mandarim-de-Lacerda CA. Browning of the subcutaneous adipocytes in diet-induced obese mouse submitted to intermittent fasting. <\/strong>Mol Cell Endocrinol <\/em>2020;513:<\/strong>110872 (doi: 10.1016\/j.mce.2020.110872<\/a>)<\/li>\r\n
              6. Martins FF, Aguila MB, Mandarim-de-Lacerda CA. Eicosapentaenoic and docosapentaenoic acids lessen the expression of PPAR\u03b3 \/ Cidec affecting adipogenesis in cultured 3T3-L1 adipocytes. <\/strong>Acta Histochemica <\/em>2020; 122: <\/strong>151504\u00a0(doi:10.1016\/<\/a>j.acthis.2020.151504)<\/li>\r\n
              7. Miranda CA, Silva-Veiga F, Martins FF, Rachid TL, Mandarim-de-Lacerda CA, Souza-Mello V. PPAR-alpha activation counters brown adipose tissue whitening: a comparative study between high-fat and high-fructose-fed mice. <\/strong>Nutrition\u00a0<\/em>2020; 78: <\/strong>110791 (doi:\u00a010.1016\/<\/a>j.nut.2020.110791)<\/li>\r\n
              8. Oliveira F, Correia B, Marinho TS, Barbosa-da-Silva S, Mandarim-de-Lacerda CA, Souza-Mello V. Anti-<\/strong>steatotic linagliptin pleiotropic effects encompasses suppression of de novo<\/em> lipogenesis and ER stress in high-fat-fed mice.<\/strong> Mol Cell Endocrinol <\/em>2020;509:<\/strong> 110804 (<\/em>doi: 10.1016\/j.mce.2020.110804<\/a>)<\/li>\r\n
              9. Ornellas F, Karise I, Aguila MB, Mandarim-de-Lacerda CA. Pancreatic islets of Langerhans: adapting cell and molecular biology to changes of metabolism<\/strong>. In: Faintuch J, Faintuch S (eds) Obesity and diabetes<\/strong>. Springer, Cham. 2020, https:\/\/doi.org\/10.1007\/978-3-030-53370-0_13<\/a><\/li>\r\n
              10. Ornellas F, Carapeto PV, Aguila MB, Mandarim-de-Lacerda CA. Sex-linked changes and high cardiovascular risk markers in the mature progeny of father, mother, or father and mother together consuming a high-fructose diet. <\/strong>Nutrition <\/em>2020; 71: <\/strong>110612\u00a0(doi:\u00a010.1016\/<\/a>j.nut.2019.110612)<\/li>\r\n
              11. Reis-Barbosa PH, Carvalho JJ, Del Sol M, Mandarim-de-Lacerda CA. Commentary on mitochondrial stereology in transmission electron microscopy<\/strong>. Int J Morphol<\/em> 2020; 38: <\/strong>26-29 (doi: 10.4067\/S0717-95022020000100026<\/a>)<\/li>\r\n
              12. Silva-Veiga FM, Miranda CS, Martins FF, Daleprane JB, Mandarim-de-Lacerda CA, Souza-Mello V. PPAR-alpha activation and DPP-4 inhibition mitigate liver<\/strong> steatosis through gut-liver axis modulation in high-fructose-fed mice. <\/strong>J Endocrinol<\/em> 2020;247:<\/strong>11-24 (doi:\u00a0<\/span>10.1530\/JOE-20-0139)<\/a><\/span><\/li>\r\n
              13. Spezani R, Silva RR, Martins FF, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Intermittent fasting, adipokines, insulin sensitivity, and hypothalamic neuropeptides in a dietary overload with high-fat or high-fructose diet in mice. <\/strong>J Nutrit Biochem <\/em>2020;83:<\/strong>108419 (doi: 10.1016\/j.jnutbio.2020.108419<\/a>)<\/li>\r\n<\/ol>\r\n

                \u00a0<\/h3>\r\n

                2019<\/h3>\r\n
                  \r\n
                1. Bargut TCL, Martins FF, Santos LP, Aguila MB, Mandarim-de-Lacerda CA. Administration of eicosapentaenoic and docosahexaenoic acids may improve the remodeling and browning in subcutaneous white adipose tissue and thermogenic markers in brown adipose tissue in mice. <\/strong>Mol Cell Endocrinol <\/em>2019;482:<\/strong>18-27\u00a0(doi:\u00a010.1016\/j.mce.2018.12.003<\/a>)<\/li>\r\n
                2. Correia BRO, Rachid TL, Glauser, JSO, Martins, FF, Mandarim-de-Lacerda CA, Souza-Mello V. Linagliptin induces browning of the subcutaneous white adipose tissue in diet-induced obese C57BL\/6 mice. <\/strong>Endocrine <\/em>2019;65:<\/strong>252-262\u00a0(doi:\u00a01<\/a>0.1007\/s12020-019-01969-y<\/a>)<\/li>\r\n
                3. Guimaraes J, Bargut TCL, Mandarim-de-Lacerda CA, Aguila MB.\u00a0Medium-chain triglyceride reinforce the hepatic damage caused by fructose intake in mice.\u00a0<\/strong>Prostaglandins, Leukotrienes and Essential Fatty Acids <\/em>2019;140:<\/strong>64-71\u00a0(doi:\u00a010.1016\/j.plefa.2018.11.005<\/a>)<\/li>\r\n
                4. Karise I, Bargut TC, Del Sol M, Aguila MB, Mandarim-de-Lacerda CA. Metformin enhances mitochondrial biogenesis and thermogenesis in brown adipocytes of mice. <\/strong>Biomed Pharmacother<\/em>\u00a02019;111;<\/strong>1156-1165\u00a0(doi: 10.1016\/j.biopha.2019.01.021<\/a>)<\/li>\r\n
                5. Maia-Ceciliano TC, Dutra RR, Aguila MB, Mandarim-de-Lacerda CA. The deficiency and the supplementation of vitamin D and liver: lessons of chronic fructose-rich diet in mice. <\/strong>J Steroid Biochem Mol Biol<\/em>\u00a02019;192:<\/strong>105399 (doi:\u00a010.1016\/j.jsbmb.2019.105399<\/a>)<\/li>\r\n
                6. Mandarim-de-Lacerda CA.\u00a0L’\u00eelot pancr\u00e9atique : ce que nous savons 150 ans apr\u00e8s Langerhans.<\/strong> Bull Acad Nationale M\u00e9d (France) <\/em>2019;203;<\/strong>670-682 \\<\/em>(doi:\u00a01<\/a>0.1016\/j.banm.2019.06.015<\/a>)<\/li>\r\n
                7. Mandarim-de-Lacerda CA. Breve hist\u00f3ria da anatomia, com \u00eanfase no sistema cardiovascular.<\/strong> Anais Acad Nac Med<\/em> 2019;190<\/strong>(2):23-33.<\/li>\r\n
                8. Mandarim-de-Lacerda, CA. Ontogenetic and phylogenetic allometry (bivariate and multivariate) for young morphologists. <\/strong>Int J Morphol\u00a0<\/em>2019;37<\/strong>(2):<\/strong>466-472 (doi: 10.4067\/S0717-95022019000200466<\/a>)<\/li>\r\n
                9. Mandarim-de-Lacerda, CA. Pancreatic islet (of Langerhans) revisited.<\/strong> Histology and Histopathology <\/em>2019;34:<\/strong>985-993 (doi:\u00a010.14670\/HH-18-118<\/a>)<\/li>\r\n
                10. Mandarim-de-Lacerda CA.\u00a0A brief introduction to the evolutionary anatomy of the skull and face in the genus Homo<\/em>.\u00a0<\/strong>J Health Med Sci\u00a0<\/em>2019;5:<\/strong>107-111 (http:\/\/www.johamsc.com\/wp-content\/uploads\/2019\/07\/JOHAMSC-52-107-111-2019-.pdf<\/a>)<\/li>\r\n
                11. Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Pancreatic islet stereology: estimation of beta cell\u00a0mass. <\/strong>Int J Morphol<\/em> 2019; 37:<\/strong>1331-1334 (doi: 10.4067\/S0717-95022019000401331)<\/a><\/li>\r\n
                12. Marinho TS, Ornellas F, Barbosa-da-Silva S, Mandarim-de-Lacerda CA, Aguila MB. Intermittent fasting beneficial effects on the steatosis and inflammation of the liver in mice fed a high-fat or a high-fructose diet. <\/strong>Nutrition <\/em>2019;65:<\/strong>103-112 (doi:\u00a010.1016\/j.nut.2019.02.020<\/a>)<\/li>\r\n
                13. Motta VF, Bargut TL, Souza-Mello V, Aguila MB, Mandarim-de-Lacerda CA. Browning is activated in the subcutaneous white adipose tissue of mice metabolically challenged with a high-fructose diet submitted to high-intensity interval training. <\/strong>J Nutr Biochem <\/em>2019;70:<\/strong>164-173 (doi:\u00a010.1016\/j.jnutbio.2019.05.008<\/a>)<\/li>\r\n
                14. Tarevnic R, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Beneficial effects of maternal swimming during pregnancy on offspring metabolism when the father is obese. <\/strong>Journal of Developmental Origins of Health and Disease\u00a0<\/em>2019;10:<\/strong>502-506 (doi: 10.1017\/S2040174418001046<\/a>)<\/li>\r\n<\/ol>\r\n\r\n

                  2018<\/h3>\r\n\r\n\r\n\r\n
                    \r\n
                  1. Borges CC, Bringhenti I, Mandarim-da-Lacerda CA, Aguila MB. Vitamin D deficiency aggravates the liver metabolism and inflammation in ovariectomized mice. <\/strong>Biomed Pharmacotherap<\/em> 2018;107:<\/strong>878-888 (doi:\u00a010.1016\/j.biopha.2018.08.075<\/a>)<\/li>\r\n\r\n\r\n\r\n
                  2. Borges CC, Salles AF, Brighenti I, Mandarim-de-Lacerda CA, Aguila MB. Vitamin D deficiency increases lipogenesis and reduces beta-oxidation in the liver of diet-induced obese mice. <\/strong>J Nutr Sci Vitaminol <\/em>2018;64<\/strong>(2):106-115 (doi: <\/em>10.3177\/jnsv.64.106<\/a>)<\/li>\r\n\r\n\r\n\r\n
                  3. Carapeto PV, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Liver metabolism in adult male mice offspring: consequences of a maternal, paternal, or both maternal and paternal high-fructose diet. <\/strong>J Development Origins Health Dis (DOHaD) <\/em>2018;9:<\/strong>450-459(doi:\u00a010.1017\/S2040174418000235<\/a>)<\/li>\r\n\r\n\r\n\r\n
                  4. Ornellas F, Bringhenti I, Mattos BA, Mandarim-de-Lacerda CA, Aguila MB. Father’s obesity programs the adipose tissue in the offspring via the local renin-angiotensin system and MAPKs pathways, especially in adult male mice. <\/strong>Eur J Nutr <\/em>2018;57:<\/strong>1901-1912(doi: 10.1007\/s00394-017-1473-4<\/a>)<\/li>\r\n\r\n\r\n\r\n
                  5. Rachid TL, Silva-Veiga FM, Graus-Nunes F, Bringhenti I, Mandarim-de-Lacerda CA, Souza-Mello V. Differential actions of PPAR-\u03b1 and PPAR-\u03b2\/\u03b4 on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice.<\/strong> PLoS ONE 13(1): e0191365 (doi: 10.1371\/journal.pone.0191365<\/a>)<\/li>\r\n\r\n\r\n\r\n
                  6. Silva-Veiga FM, Rachid TL, Oliveira L, Graus-Nunes F, Mandarim-de-Lacerda CA, Souza-Mello V. GW0742 (PPAR-beta agonist) attenuates hepatic endoplasmic reticulum stress by improving hepatic energy metabolism in mice fed a high-fat diet. <\/strong>Mol Cell Endocrinol<\/em>\u00a02018;474:<\/strong>227-237 (<\/em>doi: 10.1016\/j.mce.2018.03.013<\/a>)<\/em><\/li>\r\n<\/ol>\r\n","protected":false},"excerpt":{"rendered":"

                    2026 Aguila MB, Mandarim-de-Lacerda CA. DHA as a systems regulator of neuroinflammation: A narrative review integrating membrane organization, immunometabolism, and inflammatory resolution. Histol Histopathol 2026:25155, doi: 10.14670\/HH-25-155. Bittencourt JOA, Giannini JF, Guarnieri RS, Marinho TS, Penna-de-Carvalho A, Reis-Barbosa PH, Aguila MB, Mandarim-de-Lacerda CA. Neuroinflammation as a Central Axis in Brain Aging and Neurodegenerative Diseases: Mechanisms, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-682","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.lmmc.uerj.br\/index.php?rest_route=\/wp\/v2\/pages\/682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lmmc.uerj.br\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.lmmc.uerj.br\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.lmmc.uerj.br\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lmmc.uerj.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=682"}],"version-history":[{"count":117,"href":"https:\/\/www.lmmc.uerj.br\/index.php?rest_route=\/wp\/v2\/pages\/682\/revisions"}],"predecessor-version":[{"id":1769,"href":"https:\/\/www.lmmc.uerj.br\/index.php?rest_route=\/wp\/v2\/pages\/682\/revisions\/1769"}],"up":[{"embeddable":true,"href":"https:\/\/www.lmmc.uerj.br\/index.php?rest_route=\/wp\/v2\/pages\/5"}],"wp:attachment":[{"href":"https:\/\/www.lmmc.uerj.br\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}